TimeThursday 22nd June 2017
06:30-07:45Executive Committee Meeting, O'Callaghan Davenport Hotel
Burke Theatre, Trinity College Dublin
07:30-08:00Pre Symposium Work Shop Registration, Upper Concourse, Arts Building
08:00-12:00Pre Symposium Work Shop - Antibiotic Prophylaxis - Invite Only
COURSE LEADER: Bruno Hoen, France

- Why a randomized clinical trial on antibiotic prophylaxis of IE must be conducted
- Why an individual-based conventional RCT is not feasible
- What is a registry-based RCT
- How could a registry-based RCT be designed for assessing antibiotic prophylaxis of IE
- Preliminary data on a registry-based evaluation of the efficacy of antibiotic prophylaxis of IE in France
- Is prophylaxis of IE after dental procedure the right target? Pro/Con/alternative options

09:30 - 09:50 COFFEE BREAK

- Brainstorming on a tentative RCT design
- Feasibility by country (summary of preliminary evaluations performed in different countries before the meeting)

12:00 - 13:00 Pre Symposium Workshop Lunch
12:00 - 13:00ISCVID 2017 Registration, Upper Concourse, Arts Building Poster viewing session
13:00 - 14:00Welcome Note & Key Note Address
The future is here: from teixobactim & lugdunin to S. aureus immunotherapy
Vance Fowler, USA
14:00-15:30Antibiotic Symposium:
The Role of Old and New Antibiotics For Treating Endocarditis caused by Gram-positive pathogens


CHAIRS: Bruno Hoen, France / Philippe Moreillon, Switzerland

1: Old and new drugs. From Fosfomycin to Ceftaroline!
Jose Miro, Spain
2: The 3 “vancins”: Telavancin, Dalbavancin and Oritavancin
Michael J. Rybak, USA
3: Is there any role for linezolid and tedizolid?
Patricia Munoz, Spain
4: High-Level Daptomycin Resistance (DAP-R) in Streptococcus mitis-oralis Group of Viridans Streptococci (VGS): A ‘Perfect IE Storm’
Arnold Bayer, USA
15:30-15:50Coffee Break/ Poster viewing
Lower Concourse, Arts Building
15:50-17:30Workshop:
The Management of Prosthetic Vascular Graft Infections (PVGI)
CHAIRS: Dr Jose Miro,Spain/ Dr Deirdre Brady, Ireland/ Prof Martin O'Donohoe /Dr Ciaran O' Donnell, Ireland
1: Multidisciplinary approach of PVGI: How to build a winning team-
Barbara Hasse, Switzerland
2: Imaging diagnosis of PVGI: role of the FDG-PET/CT scan
Leo Lawler 3: Medical Therapy for PVGI presentation
Larry Baddour, USA 4: Role of surgery for the management of PVGI
Carlos Mestres, Cleveland Clinic Abu Dhabi
17:30-19:30 Oral Presentations
Bruno Hoen, Philippe Moreillon, David Durack

Epidemiology:
1: 51 Epidemiology and Outcome of Infective Endocarditis across Europe in the 21st Century: an ICE Cohort Study
Juan Ambrosioni, Spain
2: 13 Current Epidemiology of Injecting Drug Use-associated Infective Endocarditis in Victoria, Australia in the midst of increasing crystal methamphetamine use
Eugene Athan, Australia
3: 43 Characteristics and outcome of infective endocarditis in chronic hemodialysis patients: a case control study from a prospective monocentric cohort.
François Goehringer, France

Risk of IE in patients with bacteremia:
Enterococci:
4: 36 Prevalence of infective endocarditis in Enterococcus faecalis bacteraemia
Anders Dahl, Denmark
5: 15 DNOVA-score effectively identifies patients with Enterococcus faecalis bacteraemia at low risk of infective endocarditis
Andreas Berge, Sweden
Non-betahaemolytic streptococci:

6. 25 HANDOC – a handy score to classify the risk for endocarditis in patients with bacteraemia caused by non-betahaemolytic streptococci
Torgny Sunnerhagen, Sweden
S. lugdunensis:
7: 24 Not as pathogenic as we thought? The Queensland Staphylococcus lugdunensis Bacteraemia Audit
Robert Horvath, Australia
GNB
8: 48 The Epidemiology and Microbiology of Carbapenem- Resistant Pathogens Causing Bloodstream Infection in Three Tertiary- Care Hospitals in Cairo, Egypt.
Amani El Kholy, Egypt

Specific Etiological IE:
9: 74 Infectious Endocarditis by Aspergillus spp. Experience from a large multicentric national series
Maricela Valerio, Spain
10: 27 (case report) Donor Derived Disseminated Histoplasmosis in a Cardiac Transplant Recipient
Jorgelina De Sanctis and Jubran Rind, United States

Economic Burden of IE:
11: 14 Economic Burden of Infective Endocarditis due to Injection Drug Use in Australia. A Single Centre Study, Geelong, Australia.
Eugene Athan, Australia
20:30Evening Event Gala Dinner, Trinity College Dining Hall on Campus
Friday 23rd June 2017
TimeBurke Theatre, Trinity College Dublin
07:30-18:15REGISTRATION
08:30 - 09:30101 on Top Ten Publications in IE and BSI
David Durack, USA / Phillipe Moreillon, Switzerland
09:30 - 11:00ISC Sponsored Joint Symposium on BSI and Endocarditis
Blood Stream Infections in the immunocompromised host

CHAIRS: Brian O Connell, Ireland / Brian Marsh, Ireland

1: Clinical pharmacology of anti-infective in immunocompromised host
Francesco Scaglione, Italy
2: Sepsis in immunocompromised host : new frontiers
Ignacio Martin-Loeches, Ireland
3: Solid Organ Transplant patients
Paolo Grossi, Italy
4: “BSI in HIV-infected patients (including IE)”
Juan Ambrosioni, Spain
11:00-11:30Coffee Break/ Poster viewing
Lower Concourse, Arts Building
11:30 - 13:00 Symposium on Infectious Diseases in Mechanical Circulatory Support Devices
CHAIR: Carmel Halley, Ireland/ Jim McCarthy, Ireland

1: Implantable Ventricular Assist Devices Infections: 2017 Update
Steven Gordon, Cleveland Clinic, USA 2: The Epidemiology of Infection in MCS: January 2013 to December 2015
M Hannan, Ireland
3: Surgical Treatment of VAD infections- EUROMACS
Evgenij Potapov, Germany
4: New Technology in MCS
Jim Yearick, USA
13:00 - 14:00Lunch, Lower Concourse, Arts Building
&
Panel Discussion - Fascinating Failure or Surprising Success? Two cases of IE


Case 1: Larry Baddour, USA
Case 2: Steven Gordon,USA

Discussants : Michael Tolan, Kevin Walsh, Jose Miro, Jim O Neill, Bruno Hoen, Niamh O'Sullivan, Jonathon Mc Guinness, Niall Mahon, Brian O'Connell

14:00-15:10ESCMID-European Study Group (ESGIAI) and ISCVID joint symposium
CHAIRS: Efthymia Giannitsioti, Greece / Eugene Ethan Australia

1: Tavis -Lessons learned and future directions
Prof Ivan Casserly, Ireland
2: Biofilm in Chronic Infections: Problems and Prospects
Larry Kauvar, USA
3: Heart transplantation as a solution for complex Infective Endocarditis
H. R. Vikram, Mayo Clinic, USA

supported by Edwards Lifesciences
15:10-15:20Coffee Break/ Poster viewing
Lower Concourse, Arts Building
15:20-17:20Oral Session
Chairs: Margaret Hannan, Arnold Bayer, Jose Miro

Pathophysiology:
1: 21 Staphylococcus aureus von willebrand factor-binding protein supports the initiation of experimental endocarditis by lactococcus lactis, but it is dispensable in S. Aureus due to the presence of clumping factor A
José Manuel Entenza, Switzerland

Diagnosis:
2: 7 Sonication of heart valves in infective endocarditis
A. Gomes, Netherlands
3: 29 Polybacterial infective endocarditis and pathogen detection by molecular techniques
Tomas Freiberger, Czech Republic
4: 50 18F-FDG PET/CT Uptake Patterns for the Diagnosis of Prosthetic Aortic Vascular Graft Infection
Marta Hernández-Meneses, Spain

Complications:
5: 52 Risk Factors and Outcomes of Perivalvular Abscess in Left-sided Infective Endocarditis: a Prospective ICE Cohort Study
Juan Ambrosioni, Spain
6: 18 Systematic screening for splenic embolism in patients with infective endocarditis and histopathological correlates.
Cristiane Lamas, Brazil
7: 66 Assessment of risk of complications during early postoperative period in IE patients - development of a prognostic model
Alexander Nossikoff, Bulgaria
8: 55 Systematic screening for splenic embolism in patients with infective endocarditis and histopathological correlates
Cristiane Lamas, Brazil

Surgery:
9: 19 Same-day contralateral implantation of a cardiac permanent device after lead extraction for local and systemic infections
Arístides De Alarcón, Spain
10: 73 Incidence and factors associated with infective endocarditis in patients undergoing aortic valve replacement
Lauge Østergaard, Denmark
11: 31 Surgery of infective enocarditis: Is it possible to predict the preoperative risk through nonspecific scores?
Laura Varela Barca, Spain
17:20-18:20SESSION:
Molecular Diagnostics, Genetics and BSAC Guidelines

CHAIRS: Maureen Lynch,Ireland / David Durack, USA

1: Advances in the laboratory diagnosis of IE
Romney Humphries Phd UCLA
2: Implantable cardiac electronic device infections – BSAC guidelines and device salvage regimens
Jonathan Sandoe, UK
3: "Genetic predisposition for infective endocarditis: the role of SNPs"
Efthymia Giannitsioti, Greece (ESGIAI)
18:30-20:00 Evening Event - Reception at Trinity College Library in the Book of Kells Visitor Centre
Saturday 24th June 2017
TimeBurke Theatre, Trinity College Dublin
06:30-13:00REGISTRATION
07:00 - 08:30Workshop:
Towards an international consensus - Mycobacterium chimera


Aims:
1. Provide an update of current global incidence of M Chimera CT infections
2. Present an update of the local Irish cases to date
3. Present a consesus on best treatments options and durations
4. Provide and overview of the prevention strategies going forward
5. Discuss an ISCVID reporting CRF for collecting reprospective and prospective data on these cases in the future

Chairs. Jose Miro and Margaret Hannan
Discussion Panel; Barbara Hasse, Lars Nolke, David Healy, Tom Rodgers, Shaun Collins Jose M. Miro

7:00-7:05 Introduction

7:05-7:20 Barbara Hasse, (University of Zurich, Zurich, Switzerland) A global perspective on cases diagnosed and treated for M. chimera infection associated with heater coolers
7:20-7:35 Meredith Smart - Managing Director 2030 Labs UK. Northampton, UK. How best practice in hospitals can prevent Mycobacteria.

7:35-7:50 Shaun Collins – Senior Perfusionist, Beacon Hospital Dublin. Dublin. Ireland. A user perspective, the management of heater coolers in Beacon Hospital Dublin.

7:50-8:05 Mr. Lars Nolke, Cardiothoracic Surgery Department, Mater Hospital, Dublin, Ireland.
Looking for the best case-definition. The Irish cases of M. chimera infection
8:05-8:20 David Gordon to present paper. Mycobacterium chimaera infection post cardiac surgery despite extensive negative environmental surveillance and institution of recommended preventative measures. Gordon, DL, Baker RA, Papanaoum, K, Bastian I, De Pasquale, C, Howden, B, Bennetts, J

8:20-8:30 Discussion panel.
08:30 - 10:30ESGIAI sponsored symposium. Title: “Prevention of Infective Endocarditis: Should we focus on the source or substrate?"

CHAIRS: Steven Gordon, USA / Kevin Walsh, Ireland
Summary of Antibiotic Prophylaxis Workshop - Bruno Hoen

1:Discussion of what has happened since the 2007 NICE guidelines from a clinical and research perspective Martin Thornhill, UK
2: Discussion of UK studies and methodological limitations
Mark Dayer, UK
3: Role of oral disease in bacteremia and IE
Peter Lockhart, USA
4: New alternatives to preventing Endocarditis
Philippe Moreillon, France
10:30-11:00Coffee Break/ Poster viewing
Lower Concourse, Arts Building
11:30 - 13:00Endocarditis From Unique Regions
CHAIRS: Dr Christian Lamas, Brazil / Dr Larry Baddour, USA

1: “Empirical treatment regimens for endocarditis - regional variation”.
Claudio Fortes, Brazil
2: Endocarditis in Lebanon - Zeina Kanafani ,Beirut 3:Fungal IE
Hussein Risk, Egypt
4: Evaluating Outcomes in Bacteremia and Endocarditis Trials: Use of the DOOR Strategy
Tom Holland, USA
Prize giving by Jose Miro and Arnold Bayer
Closing remarks by Dr Bruno Hoen including summary of workshops and announcement of ISCVID 2019 meeting venue.

The objectives of ISCVID 2017 Dublin are to:

    • Provide an important opportunity to consolidate and record the key advances in cardiothoracic and cardiovascular infection and since the last ISCVID in 2015
    • Embrace a forward looking perspective to deliver future perspective in the area of infection prevention and management in the evolution of new cardiac and vascular devices. One that will be a lasting legacy for the field.
    • Engage new antibiotics or revitalize old antibiotics to support new scientific and new business opportunities
    • Elicit a quantum change in global engagement of the field with the device companies, pharmaceutical and industry

Topics & Themes that will be explored include:

  • Antibiotic Prophylaxis in infective endocarditis; the value of a registry – findings French registry RCT
  • Round Table Talk: Vascular Graft Infections
  • Cardiology Clinical Aspects
  • Endocarditis in the Immunocompromised Host
  • Antibiotic Stewardship in cardiovascular infections?
  • Modern Diagnosis and Treatment of Bacterial Infections
  • International Society of Chemotherapy (ISC) and ISCVID Joint Symposium on Bloodstream infections and Endocarditis
  • Modern Diagnostics and Treatment of Bacterial Infections
  • ECCMID-ISCVID Joint Symposium on Infectious Diseases in MCS Devices
  • Endocarditis from Unique Regions
  • Endocarditis 101; the top 10 papers published in the last two years on Endocarditis
  • The future of treatment of Vascular Disease, their devices and infections
  • Fungal Infections: Aspergillosis Endocarditis and Candida Endocarditis

CONFERENCE QUERIES

ISCVID 2017 Conference Account Manager for all conference logistics, programme, sponsorship and exhibition queries:

Tadhg Moriarty
Conference Partners Ltd
T:+353 (0)1 296 8688
E: Conference Organisers

CONFERENCE PROGRAMME

If you require information on the Conference Programme please email your query to:
Conference Partners Ltd
T: +353 (0)1 216 6689
E: Conference Organisers

CONFERENCE ACCOMMODATION

If you require registration, accommodation assistance please contact a member of the ISCVID 2017 delegate services team:

Conference Partners Ltd

T: +353 (0)1 216 6689
E: Conference Organisers

SPONSORSHIP & EXHIBITION

To enquire about sponsorship and exhibition packages please contact:

Conference Partners Ltd
T: +353 (0)1 2968688
E: Conference Organisers